Idiopathic CD4 T Lymphocytopenia is Associated with Increases in Immature/Transitional B Cells and Serum Levels of IL-7 Short title: ICL linked to abnormal B cells and elevated IL-7
نویسندگان
چکیده
Authors’ contributions: AM performed the research and wrote the paper with SM and ASF; DGC and CAR recruited patients, obtained and stored patient samples; AM, SM, SK, JF, and ASF contributed to the study design and analysis of the data; JF established the patient cohort and oversaw patient visits; SM and AM contributed equally to this work Financial Support: Intramural Research Program of NIAID, NIH Corresponding author: Susan Moir, Laboratory of Immunoregulation, NIAID, NIH, Building 10/6A02, 10 Center Drive, Bethesda, MD 20892; phone: 301-402-4559; fax: 301-402-5920; e-mail: [email protected] Word counts: 153 in Abstract and 1194 in Text Scientific heading: Immunobiology Blood First Edition Paper, prepublished online October 19, 2006; DOI 10.1182/blood-2006-06-031385
منابع مشابه
Idiopathic CD4+ T lymphocytopenia is associated with increases in immature/transitional B cells and serum levels of IL-7.
Idiopathic CD4+ T lymphocytopenia (ICL) is a rare heterogeneous disorder defined by CD4+ T-cell counts below 300 cells/muL in the absence of human immunodeficiency virus (HIV) infection or other known immune deficiency disorders. Here, we report the expansion of immature/transitional B cells in patients with ICL, which is associated with elevated serum levels of IL-7. Both the percentage of imm...
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